解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::In the design of parenteral delivery systems the modulation of the biodegradation of a polymer matrix represents a promising strategy to control drug release. We have investigated the degradation of ABA triblock copolymers, consisting of poly(lactide-co-glycolide) A-blocks and poly(oxyethylene) B-blocks, and PLG, poly...
journal_title:Biomaterials
pub_type: 杂志文章
doi:10.1016/s0142-9612(99)00262-8
更新日期:2000-05-01 00:00:00
abstract::A series of hydrogels composed of varying fractions of dodecyl methacrylate (DM) and 2,3-dihydroxypropyl methacrylate (GM) were prepared using ethylene glycol dimethacrylate (EGDMA) as the cross-linking agent. The study found that for a series of gels with the same monomer ratio, bulk hydration could be controlled by ...
journal_title:Biomaterials
pub_type: 杂志文章
doi:10.1016/s0142-9612(99)00245-8
更新日期:2000-04-01 00:00:00
abstract::Multilayered coatings composed of mixtures of HA and P2O5-based bioactive glasses are of potential clinical benefit in orthopaedic and dental surgery. Pre-immersion of these materials has been reported to further enhance their efficacy in vivo, although the precise biological effects of this treatment are not yet know...
journal_title:Biomaterials
pub_type: 杂志文章
doi:10.1016/s0142-9612(99)00249-5
更新日期:2000-04-01 00:00:00
abstract::The purpose of this study was to access tissue reactions to the outer prismatic (prism) and the inner nacreous (nacre) layers of the fresh water Margaritifera shell. The materials, in granule form, were implanted into the back muscles and femurs of rats for 1, 2, 4, 8 and 16 weeks. In the back muscles, a foreign body ...
journal_title:Biomaterials
pub_type: 杂志文章
doi:10.1016/s0142-9612(99)00184-2
更新日期:2000-03-01 00:00:00
abstract::In ophthalmology, there is a need for novel degradable biomaterials for e.g. controlled drug release in the vitreous body. These degradable materials should feature both excellent biocompatibility, and well-defined kinetics of degradation. In most cases, poly(D,L-lactic acid), or poly(lactic-co-glycolic acid) are used...
journal_title:Biomaterials
pub_type: 杂志文章
doi:10.1016/s0142-9612(99)00223-9
更新日期:2000-03-01 00:00:00
abstract::The degree of metal ion dissolution from Ti-6Al-4V alloy hip replacement stems subjected to various mechanical and chemical surface pretreatments was analysed in vitro. High-dissolution rates were observed for nitric acid passivated samples that had been mechanically surface treated to increase the implant surface are...
journal_title:Biomaterials
pub_type: 杂志文章
doi:10.1016/s0142-9612(99)00200-8
更新日期:2000-02-01 00:00:00
abstract::Isostatic compression has rarely been used to load calcium-phosphate biomaterials with therapeutic agents. This report, concerning four processes associating vancomycin, compares isostatic compression with wet granulation, a classical method. In the wet granulation study, vancomycin was associated with biphasic calciu...
journal_title:Biomaterials
pub_type: 杂志文章
doi:10.1016/s0142-9612(99)00139-8
更新日期:2000-02-01 00:00:00
abstract::The development of biohybrid organs (BHO) will benefit from improved membranes regarding transport and cell contacting properties. Here we describe in a first study the development and testing of membranes made of polyacrylonitrile (PAN) and polysulfone (PSU) for the immobilisation of kidney epithelial cells. Comparat...
journal_title:Biomaterials
pub_type: 杂志文章
doi:10.1016/s0142-9612(99)00147-7
更新日期:2000-01-01 00:00:00
abstract::The objective of the current investigation is to determine the soft-tissue biocompatibility of sol-gel matrices which can be used to optimize the properties of implantable glucose sensors. The biocompatibility of sol-gel matrices with heparin, dextran sulphate, Nafion, polyethylene glycol, and polystyrene sulphonate w...
journal_title:Biomaterials
pub_type: 杂志文章
doi:10.1016/s0142-9612(99)00136-2
更新日期:2000-01-01 00:00:00
abstract::Lymphocytes typically interact with implanted biomaterials through adsorbed exogenous proteins. To provide a more complete characterization of these interactions, analysis of lymphocyte migration on adsorbed extracellular matrix proteins must accompany the commonly performed adhesion studies. We report here a comparis...
journal_title:Biomaterials
pub_type: 杂志文章
doi:10.1016/s0142-9612(99)00154-4
更新日期:1999-12-01 00:00:00
abstract::Microcontact printing techniques were used to modify silicon substrates with arrays of hexagonal features of N1[3-(trimethoxysilyl) propyl]diethylenetriamine (DETA) surrounded by octadecyltrichlorosilane (OTS), which are hydrophilic, cell-adhesive and hydrophobic, non-adhesive organosilanes, respectively. In the prese...
journal_title:Biomaterials
pub_type: 杂志文章
doi:10.1016/s0142-9612(99)00163-5
更新日期:1999-12-01 00:00:00
abstract::Hydroxylated and methylated surfaces were prepared by the self-assembled monolayer technique (SAM) of alkane thiols on gold. The surfaces were used to evaluate the influence of implant surface chemistry on protein deposition and inflammatory cell response. Implants were inserted subcutaneously in the rat for 3 and 24 ...
journal_title:Biomaterials
pub_type: 杂志文章
doi:10.1016/s0142-9612(99)00115-5
更新日期:1999-11-01 00:00:00
abstract::The long-term behaviour of cellulose sponge implants, 10 x 10 x 5 mm in size, and tissue reactions in and around them were examined in the subcutaneous tissue of the rat from 1 to 60 weeks after implantation. The cellulose sponge used was filled up with connective tissue 4 to 8 weeks after implantation. Histologically...
journal_title:Biomaterials
pub_type: 杂志文章
doi:10.1016/s0142-9612(99)00094-0
更新日期:1999-11-01 00:00:00
abstract::Fracture toughness and hardness properties of CaO-P2O5 glass-reinforced hydroxyapatite composites have been assessed using indentation techniques and results calculated according to Laugier and Evans' equations. Both properties showed to be dependent upon several microstructural characteristics, namely residual porosi...
journal_title:Biomaterials
pub_type: 杂志文章
doi:10.1016/s0142-9612(99)00112-x
更新日期:1999-11-01 00:00:00
abstract::Microspheres comprised of particulate hydroxyapatites dispersed in fibrous collagen matrices were prepared. The procedure involved the droplet formation of hydroxyapatite/collagen mixture emulsified in olive oil, followed by the reconstitution of collagen in the presence of hydroxyapatite particles at 37 degrees C. Va...
journal_title:Biomaterials
pub_type: 杂志文章
doi:10.1016/s0142-9612(99)00095-2
更新日期:1999-10-01 00:00:00
abstract::With respect to the effect of material factors on calcium phosphate biomaterial-induced osteogenesis, the osteoinductive property of two kinds of porous hydroxyapatite ceramics, which were made by different producers, was investigated in dorsal muscles of dogs. One hydroxyapatite ceramic (S-HA), macroporous implants w...
journal_title:Biomaterials
pub_type: 杂志文章
doi:10.1016/s0142-9612(99)00075-7
更新日期:1999-10-01 00:00:00
abstract::A comparative in vitro assessment of 4 types of tubing representative of the materials currently used in cardiopulmonary bypass (CPB) procedures was conducted under static conditions using liquid extracts of the materials or direct contact with fresh human blood or serum. The parameters monitored were biomarkers of co...
journal_title:Biomaterials
pub_type: 杂志文章
doi:10.1016/s0142-9612(99)00051-4
更新日期:1999-09-01 00:00:00
abstract::Sol-gel derived porous silica carriers for the controlled release of proteins were synthesized using a room temperature process. The materials are intended to serve as both substrates for bone growth as well as to allow incorporated proteins such as growth factors to diffuse out and stimulate cell function and tissue ...
journal_title:Biomaterials
pub_type: 杂志文章
doi:10.1016/s0142-9612(99)00066-6
更新日期:1999-09-01 00:00:00
abstract::Brushite (dicalcium phosphate dihydrate, DCPD, CaHPO4 x 2H2O) was deposited electrolytically from calcium dihydrogen phosphate solution with and without potassium chloride (KCl) as a supporting electrolyte. The kinetics of brushite transformation to hydroxyapatite (HA, Ca5(PO4)3OH) in the presence of calcium and prote...
journal_title:Biomaterials
pub_type: 杂志文章
doi:10.1016/s0142-9612(99)00043-5
更新日期:1999-08-01 00:00:00
abstract::For a temporomandibular joint prosthesis, an estimation of the wear rate was needed, prior to patient application. Therefore, we determined the in vitro wear rate of the ball-socket articulation of this prosthesis, consisting of a metal head and an ultra-high molecular weight polyethylene (UHMWPE) cup. The basic testi...
journal_title:Biomaterials
pub_type: 杂志文章
doi:10.1016/s0142-9612(99)00042-3
更新日期:1999-08-01 00:00:00
abstract::Percutaneous implants are commonly associated with several problems, and different failure modes have been described. Infections constitute one serious complication which may lead to the removal of the implant. In contrast to infections around polymer implants, infections around skin-penetrating titanium implants anch...
journal_title:Biomaterials
pub_type: 杂志文章
doi:10.1016/s0142-9612(99)00033-2
更新日期:1999-07-01 00:00:00
abstract::Biological surface engineering using synthetic biological materials has a great potential for advances in our understanding of complex biological phenomena. We developed a simple system to engineer biologically relevant surfaces using a combination of self-assembling oligopeptide monolayers and microcontact printing (...
journal_title:Biomaterials
pub_type: 杂志文章
doi:10.1016/s0142-9612(99)00014-9
更新日期:1999-07-01 00:00:00
abstract::Bioprosthetic heart valves fail as the result of two simultaneous processes: structural deterioration and calcification. Leaflet deterioration and perforation have been correlated with regions of highest stress in the tissue. The failures have long been assumed to be due to simple mechanical fatigue of the collagen fi...
journal_title:Biomaterials
pub_type: 杂志文章
doi:10.1016/s0142-9612(99)00013-7
更新日期:1999-06-01 00:00:00
abstract::Collagenous xenografts made from kangaroo tail tendon cross-linked with glutaraldehyde have a potential application in the reconstruction of massive digital tendon deficits. However, a limitation to the clinical use of these xenografts has been the optimization of collagen cross-linking, and subsequent bio-incorporati...
journal_title:Biomaterials
pub_type: 杂志文章
doi:10.1016/s0142-9612(98)90187-9
更新日期:1999-06-01 00:00:00
abstract::In order to clarify the role of a primer on the adhesion between dental precious metals and resin, surface-enhanced Raman scattering (SERS) technique has been applied to the structural analysis of the adhesive monomer, 6-(N-(4-vinylbenzyl)propylamino)-1,3,5-triazine-2, 4-dithione (VBATDT) adsorbed on colloidal Au surf...
journal_title:Biomaterials
pub_type: 杂志文章
doi:10.1016/s0142-9612(98)00238-5
更新日期:1999-05-01 00:00:00
abstract::This article reports a novel preparation method of poly(ethylene glycol) (PEG)-polystyrene (PST) amphiphilic block copolymers with well-defined block lengths by using photopolymerization of an iniferter, benzyl N,N-diethyldithiocarbamate. PEG macroiniferters, which were prepared by end-capping of PEG monomethyl ethers...
journal_title:Biomaterials
pub_type: 杂志文章
doi:10.1016/s0142-9612(98)00252-x
更新日期:1999-05-01 00:00:00
abstract::The effect of anodization on passive dissolution of titanium was studied by measuring titanium levels in peritoneal leukocytes and tissues of laboratory animals with titanium plates implanted into the peritoneal cavity. Fifteen Sprague-Dawley rats were assigned randomly to three treatment groups of five animals. One g...
journal_title:Biomaterials
pub_type: 杂志文章
doi:10.1016/s0142-9612(98)00225-7
更新日期:1999-04-01 00:00:00
abstract::The stability of alginate-chitosan capsules was shown to depend strongly on the amount of chitosan bound to the capsules. When the capsules were made by dropping a solution of sodium alginate into a chitosan solution (one-stage procedure), all the chitosan was located in a thin alginate-chitosan membrane on the surfac...
journal_title:Biomaterials
pub_type: 杂志文章
doi:10.1016/s0142-9612(98)00230-0
更新日期:1999-04-01 00:00:00
abstract::Sintered bovine cancellous bone exhibited excellent biocompatiblity, high porosity and have an interconnecting porous structure allowing for bone ingrowth. However, the main mineral constitution of sintered bovine bone-hydroxyapatite (Ca10(PO4)6(OH)2, HAP) seems to be too stable in vivo. For improving its bioactivity,...
journal_title:Biomaterials
pub_type: 杂志文章
doi:10.1016/s0142-9612(98)00193-8
更新日期:1999-03-01 00:00:00
abstract::Topographical cues, independent of biochemistry, generated by the extracellular matrix may have significant effects upon cellular behavior. Studies have documented that substratum topography has direct effects on the ability of cells to orient themselves, migrate, and produce organized cytoskeletal arrangements. Basem...
journal_title:Biomaterials
pub_type: 杂志文章,评审
doi:10.1016/s0142-9612(98)00209-9
更新日期:1999-03-01 00:00:00
abstract::The use of a composite graft of bovine trabecular demineralized bone matrix (DBM) and perichondrium has been found a reliable method for in vivo generation of cartilage. In the present study, the mechanism whereby this commercially available matrix increases cartilage formation was investigated. First, the time course...
journal_title:Biomaterials
pub_type: 杂志文章
doi:10.1016/s0142-9612(98)00165-3
更新日期:1999-02-01 00:00:00
abstract::Tetragonal zirconia polycrystal (TZP) is a new interesting ceramic for the manufacture of medical devices. Its wide use in orthopedic and odontoiatric implants was limited till now by the high chemical and radiochemical impurities of the raw materials. Purification processes now available allow to obtain high purity c...
journal_title:Biomaterials
pub_type: 杂志文章
doi:10.1016/s0142-9612(98)00182-3
更新日期:1999-02-01 00:00:00
abstract::Alginate hydrogels are used extensively in cell encapsulation, cell transplantation, and tissue engineering applications. Alginates possess many favorable properties required in biomaterials, but are unable to specifically interact with mammalian cells. We have therefore covalently modified alginate polysaccharides wi...
journal_title:Biomaterials
pub_type: 杂志文章
doi:10.1016/s0142-9612(98)00107-0
更新日期:1999-01-01 00:00:00
abstract::This study was undertaken to investigate the relative importance of a hydroxyapatite (HA) coating and the macrotexture of titanium implants to the quality of bony ingrowth and fixation. Various types of titanium cylinders were implanted into the cancellous bone of the intercondylar region of the distal femur of the do...
journal_title:Biomaterials
pub_type: 杂志文章
doi:10.1016/s0142-9612(98)00011-8
更新日期:1999-01-01 00:00:00
abstract::Various compositions of Na2OCaO-P2O5 glasses are prepared to estimate glass formation, dissolution properties and cytotoxicity. In the wide composition range of 40 mol% of P2O5 or more, clear glass samples were obtained. The estimated glass forming region was consistent with other ternary phosphate glass systems. The ...
journal_title:Biomaterials
pub_type: 杂志文章
doi:10.1016/s0142-9612(98)00136-7
更新日期:1998-12-01 00:00:00
abstract::Synthetic hydroxyapatite particles of two median sizes and different morphologies have been used to manufacture hydroxyapatite reinforced high density polyethylene composites (HAPEX) for medical applications. The effects of hydroxyapatite particle size on properties of the resultant composites were investigated using ...
journal_title:Biomaterials
pub_type: 杂志文章
doi:10.1016/s0142-9612(98)00154-9
更新日期:1998-12-01 00:00:00
abstract::The FRP wires 0.5 mm in diameter with a multiple fiber structure were fabricated by drawing the fiber polymer complex at 250 degrees C for an esthetic, transparent orthodontic wire. Biocompatible CaO-P2O5-SiO2-Al2O3 (CPSA) glass fibers of 8-20 microm in diameter were oriented unidirectionally in the longitudinal direc...
journal_title:Biomaterials
pub_type: 杂志文章
doi:10.1016/s0142-9612(98)00127-6
更新日期:1998-12-01 00:00:00
abstract::Human cell therapy applications in tissue engineering, such as the ex vivo production of hematopoietic cells for transplantation, have recently entered the clinic. Although considerable effort has been focused on the development of biological processes to generate therapeutic cells, little has been published on the de...
journal_title:Biomaterials
pub_type: 杂志文章
doi:10.1016/s0142-9612(98)00101-x
更新日期:1998-11-01 00:00:00
abstract::This is the first report on a series of studies of the crystallinity of bone tissues. The measurements were done at the microfocused diffraction beamline at ERSF (European Synchrotron Radiation Facility) as a feasibility test on various aspects on microdiffraction analysis. Beside the crystal structure, crystallite si...
journal_title:Biomaterials
pub_type: 杂志文章
doi:10.1016/s0142-9612(98)00120-3
更新日期:1998-11-01 00:00:00
abstract::We report here the study of the biocompatibility of a bone graft material, the Pyrost, using a previously established in vitro model of human osteoblasts. The effect of this material on cell proliferation was evaluated by the MTS assay. Results indicated the absolute absence of cytotoxic or cytostatic effect of Pyrost...
journal_title:Biomaterials
pub_type: 杂志文章
doi:10.1016/s0142-9612(98)00090-8
更新日期:1998-10-01 00:00:00